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1′-Hydroxymidazolam-d4
$1,750
Only 1000 item(s) left in stock.
Products Details
Product Description
– 1′-Hydroxymidazolam-d4 is the deuterium labeled 1′-Hydroxymidazolam. 1′-Hydroxymidazolam is a primary active metabolite of Midazolam, and it is a neuronal depressant agent. 1′-Hydroxymidazolam could inhibit neuronal activity add to the effects of Midazolam[1][2].
Web ID
– HY-118645S
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H9D4ClFN3O
References
– [1]Hasegawa T, et, al. Increase in the systemic exposure of primary metabolites of Midazolam in rat arising from CYP inhibition or hepatic dysfunction. Drug Metab Pharmacokinet. 2017 Feb; 32(1): 69-76. |[2]Balk M, et, al. Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Sci Rep. 2017 Jun 14; 7(1): 3503. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
CAS Number
– 1781843-10-4
Molecular Weight
– 345.79
SMILES
– OCC1=NC=C2CN=C(C3=C(C([2H])=C([2H])C([2H])=C3[2H])F)C4=CC(Cl)=CC=C4N12
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
