Download Files:
Products Details
Product Description
– 1-(4-Hydroxy-2-methoxyphenyl)-3-(4-hydroxy-3-prenylphenyl), isolated from Broussonetia kazinoki, shows in vitro inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 13.00 μM. PTP1B is a negative regulator of insulin action and an important mediator in the pathogenesis of insulinresistance and non-insulin dependent diabetes mellitus. PTP1B is regarded as a significant target for type 2 diabetes[1].
Web ID
– HY-N1743
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C21H26O3
References
– [1]Jing-Jing Xue, et al. Flavans and diphenylpropanes with PTP1B inhibition from <i>Broussonetia kazinoki</i>. Fitoterapia. 2018 Oct;130:37-42.
CAS Number
– 376362-03-7
Molecular Weight
– 326.43
SMILES
– OC1=CC=C(CCCC2=CC=C(O)C=C2OC)C=C1C/C=C(C)C
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
