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Product Description
– β2AR agonist /M-receptor antagonist-1 is a potent dual muscarinic antagonist/beta 2 agonist (MABA). β2AR agonist /M-receptor antagonist-1 potently relaxes either Carbachol (HY-B1208)-induced contraction, in the absence (MABA) or presence of Propranolol (M3; HY-B1208), or Histamine (HY-B1204)-induced contraction (β2)[1][2].
Web ID
– HY-148533
Shipping
– Room temperature
Molecular Formula
– C33H40FN5O5S2
References
– [1]Huihui Ti, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem. 2019 Jul 11;62(13):5944-5978.|[2]Fiorella Pastore, et al.In vitro pharmacological characterization of the novel inhaled bronchodilator CHF6366 acting as dual muscarinic antagonist/β2-agonist (MABA). European Respiratory Journal 2017 50: PA1805.
CAS Number
– 2772700-36-2
Molecular Weight
– 669.83
SMILES
– O=C(C1=CN=C(C(C)C)S1)N2CC3(OCC2)CCN(CC3)CC4=CC(CCNC[C@@H](C5=C6C(NC(S6)=O)=C(C=C5)O)O)=C(C=C4)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Adrenergic Receptor;mAChR
Isoform
– β adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
