Download Files:
β-Spaglumic acid
$29 – $47
Products Details
Product Description
– β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (Ki=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies[1][2].
Web ID
– HY-130553
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C11H16N2O8
References
– [1]Yourick DL, et al. N-acetylaspartylglutamate and beta-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures. Brain Res. 2003 Nov 21;991(1-2):56-64. |[2]Wroblewska B, et al. β-NAAG rescues LTP from blockade by NAAG in rat dentate gyrus via the type 3 metabotropic glutamate receptor. J Neurophysiol. 2001 Mar;85(3):1097-106.
CAS Number
– 4910-46-7
Molecular Weight
– 304.25
SMILES
– O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Aminopeptidase;mGluR
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
