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α-Hydroxyglutaric acid-d4 (disodium)
SKU
HY-113038AS1-Get quote
Category Isotope-Labeled Compounds
Tags Cancer, Endogenous Metabolite;Histone Demethylase, Epigenetics;Metabolic Enzyme/Protease
Products Details
Product Description
– α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[2].
Web ID
– HY-113038AS1
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C5H2D4Na2O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.
CAS Number
– 2483831-91-8
Molecular Weight
– 196.10
SMILES
– O=C(O[Na])CC([2H])([2H])C(O[2H])([2H])C(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Histone Demethylase
Pathway
– Epigenetics;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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