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Product Description
– (±)-Epicatechin-13C3 is the 13C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].
Web ID
– HY-N0001S
Shipping
– Room temperature
Molecular Formula
– C12 13C3H14O6
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.|[3]Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260.|[4]Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31.
CAS Number
– 1217780-28-3
Molecular Weight
– 293.25
SMILES
– O[13C@H]1[13C@@H](C2=CC(O)=C(C=C2)O)OC3=CC(O)=CC(O)=C3[13CH2]1
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– COX;Endogenous Metabolite;Ferroptosis;Isotope-Labeled Compounds
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;Others
Product type
– Isotope-Labeled Compounds
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