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α-NETA
SKU
HY-138097-10 mg
Category Reference compound
Tags Aldehyde Dehydrogenase (ALDH);Apoptosis;Cholinesterase (ChE), Apoptosis;Metabolic Enzyme/Protease;Neuronal Signaling, Cancer
$75 – $490
Products Details
Product Description
– α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity[1][2].
Web ID
– HY-138097
Storage Temperature
– 4°C (Powder, protect from light, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C16H20INO
References
– [1]Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71.|[2]Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9(12):e112925.|[3]Qiao L, et al. α-NETA induces pyroptosis of epithelial ovarian cancer cells through the GSDMD/caspase-4 pathway. FASEB J. 2019 Nov;33(11):12760-12767.
CAS Number
– 115066-04-1
Molecular Weight
– 369.24
Compound Purity
– 98.0
SMILES
– O=C(CC[N+](C)(C)C)C1=CC=CC2=C1C=CC=C2.[I-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– Aldehyde Dehydrogenase (ALDH);Apoptosis;Cholinesterase (ChE)
Isoform
– AChE;ALDH1
Pathway
– Apoptosis;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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