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α-Hydroxyglutaric acid (disodium)
$38 – $150
Products Details
Product Description
– α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Web ID
– HY-113038A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C5H6Na2O5
References
– [1]Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.
CAS Number
– 40951-21-1
Molecular Weight
– 192.08
Compound Purity
– 98.0
SMILES
– O=C(O[Na])C(O)CCC(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O : 125 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Endogenous Metabolite;Histone Demethylase
Isoform
– Human Endogenous Metabolite;Microbial Metabolite
Pathway
– Epigenetics;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
