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α-Cyano-4-hydroxycinnamic acid
SKU
HY-107641-10mM/1mL
Category Reference compound
Tags Membrane Transporter/Ion Channel, Metabolic Disease, Monocarboxylate Transporter
$55 – $132
Products Details
Product Description
– α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].
Web ID
– HY-107641
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C10H7NO3
References
– [1]A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148(1): 85-96.|[2]Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32(6):1845-56.|[3]Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405(12):4289-93.
CAS Number
– 28166-41-8
Molecular Weight
– 189.17
Compound Purity
– 99.98
SMILES
– O=C(O)/C(C#N)=C/C1=CC=C(O)C=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 250 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Monocarboxylate Transporter
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.