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RN-1 (dihydrochloride)
$140 – $1,450
Products Details
Product Description
– RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively[1][2].
Web ID
– HY-110130
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H31Cl2N3O2
References
– [1]Ramesh Neelamegam, et al. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128.|[2]Shuaiying Cui, et al. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16;126(3):386-96.|[3]Sergiy Konovalov, et al. Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res. 2013 Oct 29;6(1):75.
CAS Number
– 1781835-13-9
Molecular Weight
– 452.42
Compound Purity
– 99.75
SMILES
– O=C(N1CCN(C)CC1)CN[C@@H]2[C@@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)C2.Cl.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Cardiovascular Disease
Solubility
– H2O : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Histone Demethylase
Isoform
– KDM1/LSD1
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
