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Eliapixant
$166 – $2,700
Products Details
Product Description
– Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].
Web ID
– HY-109170
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H21F3N4O3S
References
– [1]Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.|[2]Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561.
CAS Number
– 1948229-21-7
Molecular Weight
– 478.49
Compound Purity
– 99.69
SMILES
– C[C@H](C1=CN=C(C(F)(F)F)N=C1)NC(C2=CC(O[C@@H]3CCOC3)=CC(C4=NC=C(S4)C)=C2)=O
Clinical Information
– Phase 2
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– P2X Receptor
Isoform
– P2X3 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
