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Ro 0437626
SKU
HY-108673-Get quote
Category Reference compound
Tags Cancer, Membrane Transporter/Ion Channel, P2X Receptor
Products Details
Product Description
– Ro 0437626 is a selective purinergic (P2X1) receptor antagonist (IC50 = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC50 > 100 μM)[1].
Web ID
– HY-108673
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H35N5O4S
References
– [1]Jaime-Figueroa S, et al. Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorg Med Chem Lett. 2005;15(13):3292-3295.|[2]Harper MT, et al. Phorbol ester-evoked Ca2+ signaling in human platelets is via autocrine activation of P(2X1) receptors, not a novel non-capacitative Ca2+ entry. J Thromb Haemost. 2010;8(7):1604-1613.|[3]King BF, et al. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol. 2004;142(3):519-530.
CAS Number
– 134362-79-1
Molecular Weight
– 525.66
SMILES
– O=C(C1=NC2=CC=CC=C2N1)N[C@H](CC3=CSC=N3)C(N[C@@H](CC4CCCCC4)[C@@H](O)[C@H](C5CC5)O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– P2X Receptor
Isoform
– P2X1 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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