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RS-25344 (hydrochloride)
$100 – $950
Products Details
Product Description
– RS-25344 hydrochloride is a selective cAMP-phosphodiesterase 4 (PDE 4; PDE IV) inhibitor with an IC50 of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC50 of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects[1][2].
Web ID
– HY-108621
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C19H14ClN5O4
References
– [1]Will McDonough, et al. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice. FASEB J. 2020 Sep;34(9):12533-12548.|[2]J D Fisch, et al. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod. 1998 May;13(5):1248-54.|[3]T Kaneko, et al. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal. 1995 Jul;7(5):527-34.
CAS Number
– 152815-28-6
Molecular Weight
– 411.80
Compound Purity
– 99.50
SMILES
– [H]Cl.O=C1N(C2=CC=CC([N+]([O-])=O)=C2)C3=NC=CC=C3C(N1CC4=CC=NC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– Phosphodiesterase (PDE)
Isoform
– PDE1;PDE2;PDE3;PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
