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WHI-P258
$35 – $510
Products Details
Product Description
– WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].
Web ID
– HY-108419
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C16H15N3O2
References
– [1]Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.|[2]Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.
CAS Number
– 21561-09-1
Molecular Weight
– 281.31
Compound Purity
– 99.61
SMILES
– COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 31.25 mg/mL (ultrasonic)
Target
– JNK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
