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Products Details
Product Description
– WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].
Web ID
– HY-107640
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C33H31N3O7S
References
– [1]James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.|[2]Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.
CAS Number
– 307002-73-9
Molecular Weight
– 613.68
SMILES
– O=C(C1=CC2=C(C=CC=C2)O1)NCCOC3=CC=C(S(=O)(N(CC4=CC=CC=C4)C5=C(C)C=C(C)C=C5C(NO)=O)=O)C=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– MMP
Isoform
– MMP-1;MMP-13;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
