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Gedunin
$500 – $1,500
Products Details
Product Description
– Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research[3].
Web ID
– HY-107577
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C28H34O7
References
– [1]Shaikh J Uddin, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytother Res. 2007 Aug;21(8):757-61.|[2]Gary E L Brandt, et al. Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary structure-activity relationships. J Med Chem. 2008 Oct 23;51(20):6495-502|[3]Seshu Vardhan, et al. Virtual screening by targeting proteolytic sites of furin and TMPRSS2 to propose potential compounds obstructing the entry of SARS-CoV-2 virus into human host cells. J Tradit Complement Med. 2021 Apr 12.
CAS Number
– 2753-30-2
Molecular Weight
– 482.57
Compound Purity
– 98.0
SMILES
– O=C1[C@](O2)([H])[C@@]32[C@](CC[C@]4([H])[C@@]5(C)C=CC(C(C)(C)[C@]5([H])C[C@@H](OC(C)=O)[C@]43C)=O)(C)[C@H](C6=COC=C6)O1
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– HSP
Isoform
– HSP90
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
