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Product Description
– Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1][2][3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].
Web ID
– HY-107031
Shipping
– Room temperature
Molecular Formula
– C16H18N2
References
– [1]M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.|[2]M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.|[3]H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8.|[4]J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70.|[5]A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7.|[6]Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9.
CAS Number
– 21730-16-5
Molecular Weight
– 238.33
SMILES
– CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– iGluR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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