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BMS-345541 (hydrochloride)
$64 – $715
Products Details
Product Description
– BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
Web ID
– HY-10518
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H18ClN5
Citations
– Cancer Cell. 2015 Mar 9;27(3):409-25. |Cell Res. 2019 Mar;29(3):193-205. |Cell Syst. 2018 Apr 25;6(4):424-443.e7.|Harvard Medical School LINCS LIBRARY|J Mol Med. 2020 Oct;98(10):1479-1491.|Aging (Albany NY). 2021 Aug 10;13(15):19088-19107.|Am J Physiol Endocrinol Metab. 2021 Feb 15.|Biochem Biophys Res Commun. 2023 Nov 5, 680, Pages 127-134.|Biomed Pharmacother. 2020 Jul;127:110116.|Front Microbiol. 2021 Feb 2;12:607451.|Int Immunopharmacol. 2021 Oct 26;101(Pt A):108264.|J Dent Res. 2019 Jul;98(8):896-903.|J Pharmacol Sci. 2023 Dec, 153(4), 188-196.|J Vet Sci. 2023 Sep 4;24(5):e72.|J Virol. 2019 Nov 26;93(24):e01499-19.|Nat Metab. 2023 Mar 6.|PLoS Comput Biol. 2020 Jun 26;16(6):e1007901.|Research Square Print. October 27th, 2022.|Sci Transl Med. 2021 Jan 27;13(578):eaba7308.
References
– [1]Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960.|[2]Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456.|[3]MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511.
CAS Number
– 547757-23-3
Molecular Weight
– 291.78
Compound Purity
– 99.90
SMILES
– CC1=CN=C2C(NCCN)=NC3=CC=C(C=C3N21)C.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 20 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– IKK
Isoform
– IKK-α;IKK-β
Pathway
– NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
