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Lys-[Des-Arg9]Bradykinin (TFA)
$120 – $500
Products Details
Product Description
– Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors[1][2].
Web ID
– HY-103295A
Storage Temperature
– -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C52H74F3N13O13
References
– [1]Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9.|[2]L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77.|[3]G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003.
CAS Number
– 2763588-90-3
Molecular Weight
– 1146.22
Compound Purity
– 99.48
SMILES
– O=C([C@H]1N(CCC1)C([C@H](CCCNC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N2[C@@H](CCC2)C(NCC(N[C@H](C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O.OC(C(F)(F)F)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology
Solubility
– DMSO : 110 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Bradykinin Receptor
Isoform
– Bradykinin B1 Receptor (B1R)
Pathway
– GPCR/G Protein
Product type
– Peptides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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