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Products Details
Product Description
– Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.
Web ID
– HY-102007
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C52H65N3O8P
Citations
– Exp Ther Med. September 2, 2021.|Cancer Lett. 2022 Sep 13;215915.|Clin Cancer Res. 2022 Mar 4;clincanres.0833.2021.|Elife. 2021 Jun 16;10:e63104.|Front Biosci (Landmark Ed). 2023 Sep 26, 28(9), 227.|Nature. 2020 Mar;579(7799):433-437. |Research Square Preprint. 2020 Sep.|SSRN. 2023 Jul 11.
References
– [1]Markus D. Siegelin, et al. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011 Apr 1; 121(4): 1349–1360.
CAS Number
– 1131626-46-4
Molecular Weight
– 891.06
SMILES
– O=C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)C(NCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=C(C[C@H](C[C@@H]2OC)C)C1=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HSP
Isoform
– HSP90
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
