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L-701252
$161 – $550
Products Details
Product Description
– L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].
Web ID
– HY-101101
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C13H10ClNO3
References
– [1]Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154.|[2]Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242.
CAS Number
– 151057-13-5
Molecular Weight
– 263.68
Compound Purity
– 99.86
SMILES
– O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C(C3CC3)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– iGluR
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
