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L-threo-3-Hydroxyaspartic acid
$409 – $655
Products Details
Product Description
– L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].
Web ID
– HY-100801
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C4H7NO5
References
– [1]Hara
R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient
Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor
A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54|[2]Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.
CAS Number
– 7298-99-9
Molecular Weight
– 149.10
SMILES
– N[C@@H]([C@H](O)C(O)=O)C(O)=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– EAAT
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
