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Zabadinostat
$77 – $1,177
Products Details
Product Description
– Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively. Zabadinostat has no activity against HDAC class II. Zabadinostat has antitumor activity[1][2].
Web ID
– HY-100748
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H29N5O
References
– [1]Eyre TA, et al. A phase 1 study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer. Cancer. 2019 Jan 1;125(1):99-108.|[2]Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma – the holy grail for HDAC inhibitors? Oncotarget. 2018 Dec 18;9(99):37280-37281.
CAS Number
– 934828-12-3
Molecular Weight
– 403.52
Compound Purity
– 99.81
SMILES
– O=C(NC1=C(N)C=CC=C1)C2=CC=C(C3CCN(CC4=CN(C)N=C4C)CC3)C=C2
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– DMSO : ≥ 31 mg/mL
Target
– HDAC
Isoform
– HDAC1;HDAC2;HDAC3
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
