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Y-33075
$234 – $1,307
Products Details
Product Description
– Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
Web ID
– HY-10067
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H16N4O
Citations
– J Cell Physiol. 2021 Jun 27.|Patent. US20170349879A1.|PLoS One. 2023 Jan 31;18(1):e0270288.|Stem Cell Rep. 2020 Jan 14;14(1):49-59.|Adv Sci (Weinh). 2022 Mar 3;e2104682.|Cell. 2018 Jul 26;174(3):636-648.e18.|Harvard Medical School LINCS LIBRARY|J Adv Res. 2023 Oct 6:S2090-1232(23)00299-0.|Nat Commun. 2020 Jan 3;11(1):88.|Neurotox Res. 2013 Apr;23(3):238-48.|Science. 2017 Dec 1;358(6367):eaan4368.
References
– [1]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70.|[2]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11.|[3]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222
CAS Number
– 199433-58-4
Molecular Weight
– 280.32
Compound Purity
– 99.19
SMILES
– O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic;warming)|H2O : 1 mg/mL (ultrasonic;heat to 60°C)
Target
– ROCK
Isoform
– ROCK
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
