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Products Details
Product Description
– 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson’s disease[1][2].
Web ID
– HY-100642
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C15H13NO5
References
– [1]Jorga K, et al. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase. Br J Clin Pharmacol. 1999 Oct;48(4):513-20.|[2]Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson’s disease. Synapse. 2002 Mar 1;43(3):201-7.
CAS Number
– 134612-80-9
Molecular Weight
– 287.27
SMILES
– O=C(C1=CC([N+]([O-])=O)=C(O)C(OC)=C1)C2=CC=C(C)C=C2
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– COMT
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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