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Products Details
Product Description
– EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor.
Web ID
– HY-100520
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H33N9O3S
References
– [1]Chan BK, et al. Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor. J Med Chem. 2016 Oct 13;59(19):9080-9093.
CAS Number
– 1643497-70-4
Molecular Weight
– 551.66
SMILES
– O=S(N(N=C1)C=C1C2=NC=CC(NC3=NC=C(C(N4CC(C(C)(O)C)C4)=NN5[C@H](CC)C)C5=C3)=N2)(C6CC6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
