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SRI-011381 (hydrochloride)
$80 – $790
Products Details
Product Description
– SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].
Web ID
– HY-100347A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C20H32ClN3O
Citations
– Biomed Res Int. 2020 Nov 16;2020:8039840.|Biosci Rep. 2020 Nov 27;40(11):BSR20201545.|Cancer Cell Int. 2022 May 16;22(1):191.|Cell Commun Signal. 2023 Jul 4;21(1):168.|Cell Cycle. 2021 Jan 26;1-15.|Cell Mol Biol Lett. 2023 Feb 27;28(1):15.|Chem Res Toxicol. 2022 Feb 21;35(2):233-243.|Curr Med Sci. 2019 Aug;39(4):534-540.|Dev Comp Immunol. 2018 Nov;88:144-151. |Drug Dev Res. 2019 Nov;80(7):992-999. |Eur J Pharmacol. 2021 Oct 5;908:174356.|Evid Based Complement Alternat Med. 2023 Jan 12;2023:6018375.|Exp Eye Res. 2019 Mar 23;182:44-56.|J Cell Mol Med. 2021 Apr;25(7):3272-3283.|Life Sci. 2021 Aug 15;279:119359.|Mol Cell Biochem. 2019 Jun;456(1-2):95-104. |Mol Med Rep. 2021 Nov;24(5):758.|Nature. 2023 Jan;613(7942):120-129.|Phytomedicine. 1 June 2022, 154234.|Phytomedicine. 2022 Mar 21;100:154067.|Reprod Domest Anim. 2022 Oct 28.|Research Square Preprint. 2020 Dec.|Theranostics. 2021; 11(17):8480-8499.|Cell Immunol. 2023 Nov 2, 104781.|Dis Markers. 2022 May 7;2022:9230647.|J Agric Food Chem. 2022 Aug 25.|Phytother Res. 2022 Nov 28.
References
– [1]Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.|[2]Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499.
CAS Number
– 2070014-88-7
Molecular Weight
– 365.94
Compound Purity
– 99.97
SMILES
– O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3.Cl[H]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– TGF-beta/Smad
Pathway
– Stem Cell/Wnt;TGF-beta/Smad
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
