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Rotenone
$50 – $108
Products Details
Product Description
– Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
Web ID
– HY-B1756
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H22O6
References
– [1]Khadrawy YA, et al. Cerebellar neurochemical and histopathological changes in rat model of Parkinson’s disease induced by intrastriatal injection of rotenone. Gen Physiol Biophys. 2016 Nov 30.|[2]Guan Q, et al. RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways. Neurochem Res. 2016 Nov 30.|[3]Zhang ZN, et al. Subcutaneous rotenone rat model of Parkinson’s disease: dose exploration study. Brain Res. 2016 Nov 19. pii: S0006-8993(16)30776-4.|[4]Kishore Kumar SN, et al. Morinda citrifolia mitigates rotenone-induced striatal neuronal loss in male Sprague-Dawley rats by preventing mitochondrial pathway of intrinsic apoptosis. Redox Rep. 2016 Nov 24:1-12.|[5]Li N, et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem. 2003 Mar 7;278(10):8516-25.
CAS Number
– 83-79-4
Molecular Weight
– 394.42
Compound Purity
– 99.65
SMILES
– O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C(O[C@@H](C(C)=C)C5)=CC=C14
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 0.1 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Mitochondrial Metabolism
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
