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Nortriptyline (hydrochloride)
$60 – $66
Products Details
Product Description
– Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
Web ID
– HY-B1417
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H22ClN
References
– [1]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[2]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.|[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
CAS Number
– 894-71-3
Molecular Weight
– 299.84
Compound Purity
– 99.97
SMILES
– CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C13.[H]Cl
Clinical Information
– Launched
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Drug Metabolite
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
