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Perhexiline (maleate)
$100 – $600
Products Details
Product Description
– Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina[1][2][5].
Web ID
– HY-B1334A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H39NO4
References
– [1]E. Marc Jolicoeur, et al. 27 – Refractory Angina. Chronic Coronary Artery Disease, 2018, 412-431. |[2]Zhen Ren, et al. Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline. Toxicol In Vitro. 2020 Dec;69:104987. |[3]P-P Liu, et al. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline. Oncogene. 2016 Oct 27;35(43):5663-5673. |[4]Giovanni Licari, et al. Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats. Pharmacol Res Perspect. 2018 Jun;6(3):e00406. |[5]Shiva Kant, et al. Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma. Mol Cancer Ther. 2020 Jul;19(7):1415-1422.
CAS Number
– 6724-53-4
Molecular Weight
– 393.56
Compound Purity
– 99.26
SMILES
– O=C(O)/C=CC(O)=O.C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– DMSO : 3.57 mg/mL (ultrasonic;warming;heat to 60°C)|Ethanol : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;Mitochondrial Metabolism
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
