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Deferiprone
$50 – $70
Products Details
Product Description
– Deferiprone is a potent, orally active, brain-penetrant, cell-penetrant, skin-permeable, free iron chelating agent. Deferiprone inhibits the proliferation and migration, and stimulates apoptosis in tumor cell. Deferiprone has antianemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal activity. Deferiprone can be used in cancer, cardiovascular disease, infection, inflammation, and neurological disease study[1][2][3][4][5][6][7][8].
Web ID
– HY-B0568
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C7H9NO2
References
– [1]Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.|[2]Débora C Coraça-Huber, et al. Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathogens and Disease, Volume 76, Issue 5, July 2018, fty052|[3]Shalini S. Rao, et al. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics. 2021 Apr;18(2):1081-1094.|[4]Makhdoumi P, et al. Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.J Pharm Pharmacol. 2018 Oct;70(10):1357-1368. |[5]Yanan Zhang, et al. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. J Trace Elem Med Biol. 2023 Mar;76:127113. |[6]Rui V. Simões, Inhibition of prostate cancer proliferation by Deferiprone. NMR Biomed|[7]Oded Shalev. et al. Deferiprone (L1) Chelates Pathologic Iron Deposits From Membranes of Intact Thalassemic and Sickle Red Blood Cells Both In Vitro and In Vivo.|[8]Ngan Thi Tran, et al. Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. Platelets 2020 May 18;31(4):505-512. |[9]Andrea Pagani, MD, et al. Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation.Pathog Dis. 2018 Jul 1;76(5).
CAS Number
– 30652-11-0
Molecular Weight
– 139.15
Compound Purity
– 99.95
SMILES
– O=C1C(O)=C(C)N(C)C=C1
Clinical Information
– Launched
Research Area
– Cancer; Infection; Endocrinology; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 7.14 mg/mL (ultrasonic)|H2O : 3.33 mg/mL (ultrasonic)
Target
– Apoptosis;COX;Ferroptosis;HCV
Pathway
– Anti-infection;Apoptosis;Immunology/Inflammation
Product type
– Reference compound
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