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Product Description
– Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson’s disease research[1]. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].
Web ID
– HY-B0520
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H25NO
References
– [1]Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H(1) receptors. Bioorg Med Chem. 2006 Jun 1;14(11):3625-34.|[2]Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022.
CAS Number
– 86-13-5
Molecular Weight
– 307.43
SMILES
– CN1[C@H]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@@H]1CC2
Clinical Information
– Launched
Solubility
– 10 mM in DMSO
Target
– Dopamine Receptor;Histamine Receptor;mAChR
Isoform
– D2 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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