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Product Description
– Hydralazine is a orally active antihypertensive agent, reduces peripheral resistance directly by relaxing the smooth muscle cell layer in arterial vessel. Hydralazine has antioxidant activity, as well as inhibits reactive oxygen species (ROS) release and O2·- generation with an IC50 value of 9.53 mM and 1.19 mM, respectively[1][2].
Web ID
– HY-B0464A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C8H8N4
Citations
– J Pharm Anal. 2023 Aug 11.|Neurosci Bull. 2020 Oct;36(10):1158-1170.
References
Р[1]Arce C, Segura-Pacheco B, Perez-Cardenas E, Taja-Chayeb L, Candelaria M, Due̱nas-Gonzalez A. Hydralazine target: from blood vessels to the epigenome. J Transl Med. 2006 Feb 28;4:10.|[2]Leiro JM, et al. Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages. Int Immunopharmacol. 2004 Feb;4(2):163-77.
CAS Number
– 86-54-4
Molecular Weight
– 160.18
SMILES
– N/N=C1NN=CC2=C1C=CC=C2
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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