Download Files:
Amantadine-d15
$250 – $850
Products Details
Product Description
– Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
Web ID
– HY-B0402S
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C10H2D15N
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[3]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.
CAS Number
– 33830-10-3
Molecular Weight
– 166.34
Compound Purity
– 98.0
SMILES
– [2H]C1([2H])C2(C([2H])([2H])[C@@](C3([2H])[2H])([2H])C([2H])([2H])[C@]1([2H])C([2H])([2H])[C@@]3([2H])C2([2H])[2H])N
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Influenza Virus;Orthopoxvirus;SARS-CoV
Pathway
– Anti-infection;Apoptosis
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
