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Products Details
Product Description
– Tolbutamide-13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
Web ID
– HY-B0401S1
Shipping
– Room temperature
Molecular Formula
– C11 13CH16N2O3S
References
– [1]Wray, H.L. and A.W. Harris, Adenosine 3′, 5′-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4.|[2]Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 269.32
SMILES
– O=S(C1=CC=C(C)C=C1)(NC(N[13C]CCC)=O)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Autophagy;Isotope-Labeled Compounds;Potassium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
