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Tolbutamide
$50 – $108
Products Details
Product Description
– Tolbutamide is a first-generation potassium channel blocker and an orally active hypoglycemic compound of the sulfonylurea class.
Web ID
– HY-B0401
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C12H18N2O3S
References
– [1]Wray, H.L. and A.W. Harris, Adenosine 3′, 5′-monophosphate-dependent protein kinase in adipose tissue: inhibition by tolbutamide. Biochem Biophys Res Commun, 1973. 53(1): p. 291-4.|[2]Sanchez-Alvarez, R., et al., Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up-regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation. Glia, 2006. 54(2): p. 125-34.
CAS Number
– 64-77-7
Molecular Weight
– 270.35
Compound Purity
– 99.96
SMILES
– O=S(C1=CC=C(C)C=C1)(NC(NCCCC)=O)=O
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : ≥ 34 mg/mL
Target
– Autophagy;Potassium Channel
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
