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Sulfisoxazole
$78 – $144
Products Details
Product Description
– Sulfisoxazole (Sulfafurazole) is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Web ID
– HY-B0323
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C11H13N3O3S
References
– [1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.
CAS Number
– 127-69-5
Molecular Weight
– 267.30
Compound Purity
– 99.95
SMILES
– O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection; Endocrinology
Solubility
– DMSO : ≥ 150 mg/mL
Target
– Antibiotic;Bacterial;Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– Anti-infection;GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
