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Clemastine (fumarate)
$66 – $195
Products Details
Product Description
– Clemastine (HS-592) fumarate is a selective histamine H1 receptor antagonist. Clemastine fumarate is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].
Web ID
– HY-B0298A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C25H30ClNO5
Citations
– Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.|Cell Prolif. 2021 Jan;54(1):e12953.|Microbiol Spectr. 2022 Mar 2;e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2023 Nov 28:110901.|Viruses. 2021 Jun 28;13(7):1255.|Methods Mol Biol. 2023;2683:103-111.
References
– [1]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.|[2]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.
CAS Number
– 14976-57-9
Molecular Weight
– 459.96
Compound Purity
– 99.93
SMILES
– CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
Clinical Information
– Launched
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 14.29 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– Histamine Receptor
Isoform
– H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
