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Products Details
Product Description
– Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
Web ID
– HY-B0005S1
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H23D6Cl2NO
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.
Molecular Weight
– 448.46
SMILES
– ClCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)C3=CC=C(C=C3)OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H].[H]Cl
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Estrogen Receptor/ERR;Isotope-Labeled Compounds
Pathway
– Others;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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