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Toremifene (citrate)
$66 – $125
Products Details
Product Description
– Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].
Web ID
– HY-B0005
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H36ClNO8
Citations
– J Med Chem. 2020 Oct 8;63(19):11085-11099.|Viruses. 2021 Jun 28;13(7):1255.|bioRxiv. 2020 May.|J Pharmaceut Biomed. 2020, 113870.|Patent. US11696914.|Research Square Preprint. 2020 Nov 4;rs.3.rs-100914.
References
– [1]Laura Cooper, et al. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. J Med Chem. 2020 Sep 4.|[2]Matthew R Smith, Selective Estrogen Receptor Modulators to Prevent Treatment-Related Osteoporosis.Rev Urol. 2005; 7(Suppl 3): S30-S35.|[3]Gauri J Sabnis, Luciana Macedo, Olga Goloubeva, Toremifene – Atamestane; Alone or In Combination: Predictions from the Preclinical Intratumoral Aromatase Model. J Steroid Biochem Mol Biol. 2008 January; 108(1-2): 1-7.|[4]Taneja SS, Morton R, Barnette G, Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene. J Clin Oncol. 2013 Feb 10;31(5):523-9.
CAS Number
– 89778-27-8
Molecular Weight
– 598.08
Compound Purity
– 99.82
SMILES
– ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)C3=CC=CC=C3.O=C(CC(C(O)=O)(O)CC(O)=O)O
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 0.67 mg/mL (ultrasonic)
Target
– Apoptosis;Estrogen Receptor/ERR
Pathway
– Apoptosis;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
