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4-Phenylbutyric acid
$50 – $55
Products Details
Product Description
– 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Web ID
– HY-A0281
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C10H12O2
Citations
– Acta Pharm Sin B. 5 January 2022.|Anim Nutr. 5 October 2022.|Animals (Basel). 2023 Jul 13, 13(14), 2291.|Antioxid Redox Signal. 2023 Apr 13.|Autophagy. 2021 Nov;17(11):3592-3606.|Bioact Mater. 2023 Sep,257-270.|Biochem Pharmacol. 2022 Dec 30;115404.|Biochem Pharmacol. 2022: 115343.|Biochem Pharmacol. 2023 Jun 28;115666.|BMC Complement Med Ther. 2022 May 5;22(1):125.|Br J Nutr. 2023 Sep 13;1-27.|Br J Pharmacol. 2022 May 1.|Bull Exp Biol Med. 2023 Apr 13;1-8.|Cancer Lett. 2021 Apr 6;S0304-3835(21)00153-1.|Cancer Lett. 2021 Nov 16;S0304-3835(21)00581-4.|Cell Death Dis. 2020 Apr 24;11(4):279.|Cell Death Dis. 2021 Jun 11;12(6):606.|Cell Death Dis. 2022 Nov 10;13(11):951.|Cell Death Discov. 2023 Aug 14;9(1):296.|Cell Mol Biol Lett. 2023 Oct 12;28(1):79.|Cell Stress Chaperones. 2022 Nov 28.|Cells. 2022, 11(23), 3792.|Chem Biol Interact. 2022 Aug 23;110125.|Chem Biol Interact. 2023 Jun 1;110592.|Chemosphere. 2022 Aug 7;307(Pt 2):135962.|Chemosphere. 2023 Mar 24;327:138463.|Ecotoxicol Environ Saf. 2022 Sep 21;245:114099.|Ecotoxicol Environ Saf. 2023 Mar 14;255:114725.|Elife. 2020 Dec 7;9:e61405.|Environ Int. 2023 Jan 13.|Environ Int. 2023 Sep 27:180:108228.|Environ Toxicol. 2023 May 6.|Exp Ther Med. 2023 Sep 1.|Fish Physiol Biochem. 2022 Jan 29.|Food Chem Toxicol. 2020 Feb;136:111080.|Food Chem Toxicol. 2022 Jun 28;113263.|Food Chem Toxicol. 2023 Sep 20;114033.|Foods. 2023 Apr 11, 12(8), 1616.|Free Radic Biol Med. 2023 Jun 24.|Front Cell Infect Microbiol. 14 June 2022.|Front Oncol. 2021 Jul 7;11:663600.|Front Pharmacol. 2022 Mar 21;13:854506.|Int Immunopharmacol. 2021 Dec 22;103:107842.|Int Immunopharmacol. 2021 Dec 27;103:108489.|Int J Med Sci. 2024 Jan 1; 21(2):341-356.|Int J Mol Sci. 2023, 24(2), 1015.|Int J Mol Sci. 2023, 24(3), 2749.|J Burn Care Res. 2023 Mar 4;irad029.|J Dairy Sci. 2023 May 22;S0022-0302(23)00275-8.|J Ethnopharmacol. 2022 Dec 15;116028.|J Ethnopharmacol. 2023 Oct 5;319(Pt 2):117245.|J Exp Clin Cancer Res. 2023 Jun 19;42(1):150.|J Funct Foods. 2020, 104178.|J Funct Foods. 2022, 99: 105336.|J Hazard Mater. 2023 Jan 12.|J Orthop Surg Res. 2022 Nov 16;17(1):487.|Lab Invest. 2022 Aug 8.|Life Sci. 2023 Apr 1;121656.|MedComm-Oncology. 2023 Feb 19.|Mol Biol Rep. 2023 Jun 16.|Mol Immunol. 2021 May 3;135:294-303.|Oxid Med Cell Longev. 2021 Jun 17.|Oxid Med Cell Longev. 2022 Apr 6;2022:1835900.|Oxid Med Cell Longev. 2022 May 5;2022:5695005.|PeerJ. 2022 May 12;10:e13376.|Phytother Res. 2022 Sep 9.|Research Square Preprint. 2022 Jun.|Research Square Preprint. 2023 Jul 28.|Research Square Print. 2022 Aug.|Research Square Print. October 4th, 2022.|Respir Res. 2023 Jun 2;24(1):149.|Sci Immunol. 2023 Sep 29;8(87):eabq2424.|Sci Rep. 2023 Jan 13;13(1):693.|Sci Rep. 2023 Jan 20;13(1):1147.|Sci Rep. 2023 Nov 9;13(1):19438.|Sci Total Environ. 2023 Jun 1;164620.|Small. 2022 Dec 4;e2204310.|Toxicol In Vitro. 2022: 105534.|Toxicology. 2022 May 15;473:153193.|Vet Microbiol. 2021 Feb;253:108959.|Vet Microbiol. 2023 Jan 24;279:109666.|Viruses. 2023, 15(2), 534.|Arterioscler Thromb Vasc Biol. 2022 Mar;42(3):305-325.|Autophagy. 2022 Feb 7;1-18.|Biosci Rep. 2019 Aug 7;39(8):BSR20190578.|Cell Death Dis. 2018 Nov 16;9(12):1143. |Cell Stress Chaperones. 2022 May;27(3):273-283.|Chem Biol Interact. 2023 May 3;110523.|Ecotoxicol Environ Saf. 2022 May 1;236:113508.|FEBS Open Bio. 2020 Oct;10(10):2122-2136.|Food Chem Toxicol. 2020 Jun;140:111329.|Front Oncol. 2021 Oct 27;11:722624.|Front Pharmacol. 2021 May 24;12:685895.|Int Immunopharmacol. 2021 Oct 25;101(Pt A):108281.|Int J Clin Exp Med. 2019;12(5):5184-5190.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Lett Drug Des Discover. 2019 Nov.|Nutr Metab. 2020 Jan 30;17:11.|Toxicol Res. 2021 Jan 5.|Vet Res. 2023 Mar 22;54(1):27.
References
– [1]Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.|[2]Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.|[3]Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.
CAS Number
– 1821-12-1
Molecular Weight
– 164.20
Compound Purity
– 99.98
SMILES
– O=C(O)CCCC1=CC=CC=C1
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic)
Target
– HDAC;Virus Protease
Isoform
– HDAC
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
