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Products Details
Product Description
– Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
Web ID
– HY-A0061S
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C9 13CH11F3 15N2O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.
CAS Number
– 2086328-10-9
Molecular Weight
– 299.18
SMILES
– O=[13C]1[15N](C=C(C([15NH]1)=O)C(F)(F)F)[C@]2([H])O[C@@H]([C@H](C2)O)CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HSV;Nucleoside Antimetabolite/Analog;Orthopoxvirus;Thymidylate Synthase
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Isotope-Labeled Compounds
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