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Products Details
Product Description
– Linifanib (ABT-869) (GMP) is Linifanib (HY-50751) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Linifanib is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib (GMP) promotes the generation and reprogramming of iPSCs from somatic cells[1].
Web ID
– HY-50751G
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H18FN5O
References
– [1]Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605(7909):325-331.
CAS Number
– 796967-16-3
Molecular Weight
– 375.40
SMILES
– O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PDGFR;VEGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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