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Products Details
Product Description
– Plocabulin (PM060184) is a potent microtubule inhibitor. Plocabulin is a natural product that could be isolated from the marine sponge Lithoplocamia lithistoides. Plocabulin suppresses microtubule shortening and growth. Plocabulin has anticancer activity[1][2].
Web ID
– HY-19922
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H45N3O7
References
– [1]MartÃnez-DÃez M, et, al. PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors. Biochem Pharmacol. 2014 Apr 1;88(3):291-302.|[2]Costales-Carrera A, et, al. Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay. Mar Drugs. 2019 Nov 19;17(11):648.
CAS Number
– 960210-99-5
Molecular Weight
– 571.70
SMILES
– C[C@H]([C@@H]1CC=C(OC)C(O1)=O)/C=C(C)/C=CC=C/C(N[C@H](C(N/C=CC[C@@H](OC(N)=O)C/C=CC)=O)C(C)(C)C)=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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