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XL-784
$350 – $2,500
Products Details
Product Description
– XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.
Web ID
– HY-19485
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H21ClF2N3O8S-
References
– [1]Williams JM, et al. Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy. Am J Physiol Renal Physiol. 2011 Apr;300(4):F983-98.|[2]Ennis T, et al. Effect of novel limited-spectrum MMP inhibitor XL784 in abdominal aortic aneurysms. J Cardiovasc Pharmacol Ther. 2012 Dec;17(4):417-26.
CAS Number
– 1224964-36-6
Molecular Weight
– 548.92
Compound Purity
– 98.13
SMILES
– O=C(N1CC(C(N[O-])=O)N(S(=O)(C2=CC(F)=C(OC3=CC=C(Cl)C=C3)C(F)=C2)=O)CC1)OCCOC.[0.5Mg2+]
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– DMSO : ≥ 110 mg/mL
Target
– MMP
Isoform
– MMP-1;MMP-13;MMP-2;MMP-3;MMP-8;MMP-9
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
