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Products Details
Product Description
– NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM)[1][2].
Web ID
– HY-18768A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H33ClN6O3
References
– [1]Kulsum S et al. Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by Aldehydedehydrogenase 1 A1 inhibition.|[2]Yang SM, et al. Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1(ALDH1A1). J Med Chem. 2015 Aug 13;58(15):5967-5978.
CAS Number
– 2080306-22-3
Molecular Weight
– 452.98
SMILES
– O=C(N1C)N(C)C2=C(N(CCC(C)C)C(CN3CCN(C(C4CC4)=O)CC3)=N2)C1=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aldehyde Dehydrogenase (ALDH)
Isoform
– ALDH1
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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