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Guanfacine (hydrochloride)
$38 – $295
Products Details
Product Description
– Guanfacine (hydrochloride) is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette’s syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3].
Web ID
– HY-17416
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C9H10Cl3N3O
References
– [1]Amy F T Arnsten, et al. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29.|[2]P. A. Van Zwieten, et al. The pharmacology of centrally acting antihypertensive drugs. Br J Clin Pharmacol. 1983; 15(Suppl 4): 455S–462S.|[3]Min Wang, et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20;129(2):397-410.
CAS Number
– 29110-48-3
Molecular Weight
– 282.55
Compound Purity
– 99.96
SMILES
– O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl.[H]Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Endocrinology
Solubility
– DMSO : ≥ 30 mg/mL|H2O : 20 mg/mL (ultrasonic)
Target
– Adrenergic Receptor
Isoform
– α adrenergic receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
