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UMI-77
$47 – $650
Products Details
Product Description
– UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
Web ID
– HY-18628
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H14BrNO5S2
References
– [1]Abulwerdi F, et al. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther. 2014 Mar;13(3):565-575.
CAS Number
– 518303-20-3
Molecular Weight
– 468.34
Compound Purity
– 99.66
SMILES
– O=C(O)CSC1=CC(NS(=O)(C2=CC=C(Br)C=C2)=O)=C3C=CC=CC3=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 28 mg/mL
Target
– Bcl-2 Family
Isoform
– Bcl-2;Bcl-W;Bcl-xL;Bfl-1;Mcl-1
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
