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IOWH-032
$41 – $825
Products Details
Product Description
– IOWH-032 is a a synthetic anti-secretory molecule, is a potent CFTR inhibitor with an IC50 value of 8 µM. IOWH-032 also is a anti-diarrheal agent[1][2].
Web ID
– HY-18337
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H15Br2N3O4
References
– [1]Lotti V, et al. CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells. Cells. 2022 Apr 15;11(8):1347.|[2]Thiagarajah JR, et al. CFTR inhibitors for treating diarrheal disease. Clin Pharmacol Ther. 2012 Sep;92(3):287-90.|[3]Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For
Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation|[4]de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.
CAS Number
– 1191252-49-9
Molecular Weight
– 545.18
Compound Purity
– 99.63
SMILES
– BrC1=C(O)C(Br)=CC(C2=NOC(C(NCC3=CC=C(OC4=CC=CC=C4)C=C3)=O)=N2)=C1
Clinical Information
– Phase 2
Research Area
– Infection; Metabolic Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– CFTR;SARS-CoV
Pathway
– Anti-infection;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
