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Atazanavir
$50 – $350
Products Details
Product Description
– Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].
Web ID
– HY-17367
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C38H52N6O7
Citations
– Aging Cell. 2022 Dec 20;e13750.|Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20.|Faculty of Pharmacy in Hradec Králové Department of Pharmacological and Toxicology. University of Oxford. 2019 Jul.|Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|PLoS Biol. 2020 Jan 16;18(1):e3000599. |Research Square Print. 2022 May.|bioRxiv. 2020 Apr.|Curr Protoc. 2021 Feb;1(2):e32.|Nat Commun. 2020 Sep 4;11(1):4417.|Signal Transduct Target Ther. 2021 May 29;6(1):212.
References
– [1]Havlir DV, et al. Atazanavir: new option for treatment of HIV infection. Clin Infect Dis. 2004 Jun 1;38(11):1599-604.|[2]Wood R. Atazanavir: its role in HIV treatment. Expert Rev Anti Infect Ther. 2008 Dec;6(6):785-96.|[3]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
CAS Number
– 198904-31-3
Molecular Weight
– 704.86
Compound Purity
– 99.23
SMILES
– O=C(OC)N[C@@H](C(C)(C)C)C(NN(CC1=CC=C(C2=NC=CC=C2)C=C1)C[C@H](O)[C@H](CC3=CC=CC=C3)NC([C@H](C(C)(C)C)NC(OC)=O)=O)=O
Clinical Information
– Launched
Research Area
– Infection; Cancer
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)
Target
– Cytochrome P450;Endogenous Metabolite;HIV;HIV Protease;P-glycoprotein;SARS-CoV
Isoform
– CYP3;HIV-1
Pathway
– Anti-infection;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
